Gonzalez-Lima F, Stiehl W L, Ocasio H
Eur J Pharmacol. 1984 Jul 13;102(2):289-95. doi: 10.1016/0014-2999(84)90260-7.
Repeated daily administration of LSD and related hallucinogens produces tolerance to their behavioral effects. The objective was to test whether repeated administration of bromocriptine (BC) produced behavioral tolerance. Experiments began after 4 weeks of habituation and baseline measurements. Cats were then injected daily with BC (10 mg/kg i.p.) for 7 days. The frequency of 40 different behaviors and neurological signs were scored for 60 min after one h post-injection. There was a rapid tolerance to the 'emergent' behavior induced by BC. In the case of hallucinatory-like behavior/escape, tolerance to a second dose of BC one day after a first dose was virtually complete. A substantial tolerance to BC effects such as abortive grooming, increased investigatory-play behavior and grooming occurred within one day. The decrease in sleep produced by BC was absent at the fourth day. Limb flicks and body shakes decreased but persisted until the seventh day. There was also tolerance to emotional behavior (irritability, rage, threat, flight) but motor effects (circling, ataxia, hypokinesia) remained throughout the week. Autonomic reactions were unaffected by BC. The results indicated that the psychotomimetic effects (but not the motor or autonomic) of BC showed rapid and long-lasting tolerance. These studies suggest that BC-induced alterations in cats parallel parameters of action of hallucinogens in humans.
每日重复给予麦角酸二乙酰胺（LSD）及相关致幻剂会使其行为效应产生耐受性。目的是测试重复给予溴隐亭（BC）是否会产生行为耐受性。实验在经过4周的适应期和基线测量后开始。然后猫每天腹腔注射BC（10毫克/千克），持续7天。在注射后1小时后的60分钟内，对40种不同行为和神经体征的频率进行评分。对BC诱导的“突发”行为迅速产生耐受性。就类似幻觉的行为/逃避而言，在首次给药一天后对第二剂BC的耐受性几乎完全形成。在一天内对BC的效应如未遂梳理、探究-玩耍行为增加和梳理等产生了显著耐受性。到第四天，BC导致的睡眠减少消失。肢体轻弹和身体抖动减少，但一直持续到第七天。对情绪行为（易怒、愤怒、威胁、逃避）也产生了耐受性，但运动效应（转圈、共济失调、运动减退）在整个一周内都存在。自主反应不受BC影响。结果表明，BC的拟精神病效应（但不包括运动或自主效应）表现出快速且持久的耐受性。这些研究表明，BC在猫身上诱导的变化与致幻剂在人类中的作用参数相似。
