Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Res Microbiol. 2019 Nov-Dec;170(8):374-380. doi: 10.1016/j.resmic.2019.07.003. Epub 2019 Aug 1.
FtsEX is a member of a small subclass of ABC transporters that uses mechano-transmission to perform work in the periplasm. FtsEX controls periplasmic peptidoglycan (PG) hydrolase activities in many Gram negative and positive organisms to ensure the safe separation of daughter cells during division. In these organisms FtsEX localizes to the Z ring and uses its ATPase activity to regulate its periplasmic effectors. In Escherichia coli, FtsEX also participates in building the divisome and coordinates PG synthesis with PG hydrolysis. This review discusses studies that are beginning to elucidate the mechanisms of FtsEX's various roles in cell division.
FtsEX 是 ABC 转运蛋白的一个小亚类成员，它利用机械传递在周质中做功。FtsEX 控制着许多革兰氏阴性和阳性生物体中周质肽聚糖（PG）水解酶的活性，以确保在分裂过程中安全地分离子细胞。在这些生物体中，FtsEX 定位于 Z 环，并利用其 ATP 酶活性来调节其周质效应物。在大肠杆菌中，FtsEX 还参与构建分裂体，并协调 PG 合成与 PG 水解。这篇综述讨论了一些正在开始阐明 FtsEX 在细胞分裂中的各种作用的机制的研究。
