Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Res Microbiol. 2019 Nov-Dec;170(8):338-344. doi: 10.1016/j.resmic.2019.07.004. Epub 2019 Aug 1.
The transport of peptides in microorganisms plays an important role in their physiology and behavior, both as a nutrient source and as a proxy to sense their environment. This latter function is evidenced in Gram-positive bacteria where cell-cell communication is mediated by small peptides. Here, we highlight the importance of the oligopeptide permease (Opp) systems in the various major processes controlled by signaling peptides, such as sporulation, virulence and conjugation. We underline that the functioning of these communication systems is tightly linked to the developmental status of the bacteria via the regulation of opp gene expression by transition phase regulators.
肽在微生物中的运输在它们的生理和行为中起着重要作用，既是营养源，也是感知环境的媒介。革兰氏阳性菌中，细胞间的通讯是由小肽介导的，这证明了后一种功能的存在。在这里，我们强调了寡肽渗透酶（Opp）系统在由信号肽控制的各种主要过程中的重要性，如孢子形成、毒力和共轭。我们强调，这些通讯系统的功能与细菌的发育状态密切相关，opp 基因的表达通过过渡相调节剂进行调控。
