D'Oria Mario, Mastrorilli Davide, Ziani Barbara
Division of Vascular and Endovascular Surgery, Mayo Clinic Gonda Vascular Center, Rochester, MN; Division of Vascular and Endovascular Surgery, Cardiovascular Department, University Hospital of Cattinara ASUITs, Trieste, Italy.
Division of Vascular and Endovascular Surgery, Cardiovascular Department, University Hospital of Cattinara ASUITs, Trieste, Italy.
Ann Vasc Surg. 2020 Jan;62:420-431. doi: 10.1016/j.avsg.2019.04.048. Epub 2019 Jul 31.
Endoleaks (ELs), defined as continued perfusion of the aneurysm sac despite stent-graft deployment, are the most common adverse event after endovascular aortic repair (EVAR) and account for most of the reinterventions. Type 2 EL (T2EL), caused by backflow of collateral arteries into the aneurysm sac, are the most frequently encountered and may account for the need for secondary interventions after EVAR in up to 40% of the cases. Contrast-enhanced ultrasound and magnetic resonance imaging may be better able to quantify and characterize low-flow T2EL as compared with computed tomography angiography. Support for conservative management of T2EL derives from the relatively high percentage of T2EL that will resolve spontaneously over a variable period (more than 30%) and the estimated low risk of post-EVAR rupture secondary to isolated T2EL (less than 1%). Current guidelines are that a conservative approach is appropriate for isolated T2EL without sac expansion while intervention is recommended when sac enlargement of ≥10 mm as compared with pre-EVAR is detected. Although generally safe, secondary interventions for T2EL are often unsatisfactory since persistence and recurrence are commonly encountered problems and long-term follow-up is mandatory. Further investigation is required to determine the factors associated with abdominal aortic aneurysm progression in the presence of isolated T2EL and the most cost-effective technique to manage this complication.
内漏(ELs)是指在植入覆膜支架后动脉瘤腔仍持续灌注,是血管腔内主动脉修复术(EVAR)后最常见的不良事件,也是大多数再次干预的原因。2型内漏(T2EL)由侧支动脉反流至动脉瘤腔引起,最为常见,在高达40%的病例中可能是EVAR后需要二次干预的原因。与计算机断层扫描血管造影相比,对比增强超声和磁共振成像可能更能量化和表征低流量T2EL。对T2EL采取保守治疗的依据是,相当比例的T2EL会在不同时期自发消失(超过30%),以及孤立性T2EL导致EVAR术后破裂的估计风险较低(低于1%)。目前的指南认为,对于无瘤腔扩大的孤立性T2EL,采取保守治疗是合适的,而当检测到瘤腔较EVAR术前增大≥10 mm时,则建议进行干预。虽然T2EL的二次干预通常是安全的,但往往不尽人意,因为持续存在和复发是常见问题,且必须进行长期随访。需要进一步研究以确定在存在孤立性T2EL的情况下与腹主动脉瘤进展相关的因素,以及处理该并发症的最具成本效益的技术。