缺氧诱导的血栓形成。

The stimulation of thrombosis by hypoxia.

机构信息

Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India.

Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

出版信息

Thromb Res. 2019 Sep;181:77-83. doi: 10.1016/j.thromres.2019.07.013. Epub 2019 Jul 15.

DOI:10.1016/j.thromres.2019.07.013

PMID:31376606

Abstract

Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. In this article, we review the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation could lead to the development of novel prophylactic therapies for thrombosis.

摘要

血栓形成在血栓形成的动物模型和人类群体中的缺氧条件下增加，但目前治疗血栓的方法并不能直接针对缺氧反应信号通路。缺氧对血管的反应主要由缺氧诱导转录因子（HIFs）控制，其靶基因包括几种调节血栓形成的因子。在本文中，我们综述了缺氧条件下调节血栓形成的 HIF 依赖性和 HIF 非依赖性信号通路。更好地理解缺氧诱导的血栓形成可能导致开发新的血栓形成预防治疗方法。