骨髓增生异常综合征与自身免疫的阴阳两面：自身免疫性疾病对 MDS 特异性治疗有反应的矛盾现象。
The Yin and Yang of myelodysplastic syndromes and autoimmunity: The paradox of autoimmune disorders responding to therapies specific for MDS.
机构信息
Hematology Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy.
Hematology Unit, Department of Medical Sciences, University of Cagliari, Cagliari, Italy.
出版信息
Crit Rev Oncol Hematol. 2019 Oct;142:51-57. doi: 10.1016/j.critrevonc.2019.07.018. Epub 2019 Jul 26.
The biological milieu and clinical picture of myelodysplastic syndromes (MDS) is characterised by a variety of immune mechanisms and manifestations, including an increased frequency of autoimmune disorders. The present review will try to shed some light on the potential clinical and pathogenetic implications of these immune processes in MDS by focusing on the beneficial effects exerted by some MDS-modifying therapies on autoimmune manifestations.
骨髓增生异常综合征（MDS）的生物学环境和临床表现的特点是存在多种免疫机制和表现，包括自身免疫性疾病的发病率增加。本综述将通过关注一些 MDS 修饰治疗对自身免疫表现的有益作用，尝试阐明这些免疫过程在 MDS 中的潜在临床和发病机制意义。
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