Fozza Claudio
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Hematol Oncol. 2018 Feb;36(1):15-23. doi: 10.1002/hon.2423. Epub 2017 Apr 27.
The clinical history of patients with myelodysplastic syndromes (MDS) is characterised by bone marrow insufficiency as well as by the possible evolution into acute leukaemia. However a number of reports highlight the frequent occurrence of autoimmune manifestations involving different sites and organs. The present review will first describe the clinical pictures most often observed in MDS patients. The actual burden of autoimmunity will be then addressed by focusing on the few available registry studies. Finally, the potential collateral impact of specific treatments for MDS on the evolution of autoimmune disorders will be considered.
骨髓增生异常综合征（MDS）患者的临床病史以骨髓功能不全以及可能演变为急性白血病为特征。然而，许多报告强调了涉及不同部位和器官的自身免疫表现的频繁发生。本综述将首先描述MDS患者中最常观察到的临床症状。然后将通过关注少数可用的登记研究来探讨自身免疫的实际负担。最后，将考虑MDS特定治疗对自身免疫性疾病演变的潜在附带影响。
