Department of Chemistry, Kyungpook National University, Daegu, 41566, Republic of Korea; Analytical Research Center, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.
Oil and POPs Research Group, Korea Institute of Ocean Science and Technology, Geoje, 53201, Republic of Korea; Marine Environmental Science Major, Korea University of Science and Technology, Geoje, 53201, Republic of Korea.
Chemosphere. 2019 Dec;237:124346. doi: 10.1016/j.chemosphere.2019.124346. Epub 2019 Jul 15.
In this study, developmental toxicity was increased as the oil was further degraded under natural sunlight. Detailed chemical composition of the degraded oils was examined by use of gas chromatography (GC) and (-) electrospray ionization ultrahigh resolution mass spectrometry (UHR-MS). Baseline toxicities were estimated based on chemical activities of polycyclic aromatic hydrocarbons, and it was obvious that the predicted chemical activities can not explain increased toxicity alone. However, the ultrahigh resolution mass spectral abundance of polar compounds including O and O class compounds was significantly increased as the photodegradation proceeded. Further examination of double bond equivalence values of the compounds showed that polar compounds with both non-aromatic and aromatic polar structures were increased. Statistical analysis indicates that the increased toxicity can be well explained by the increased polar compounds. Therefore, the oxygenated compounds identified in this study can play an important role in toxicity of degraded oils.
在这项研究中，随着油在自然阳光下进一步降解，发育毒性增加。通过使用气相色谱（GC）和（-）电喷雾电离超高分辨率质谱（UHR-MS）检查降解油的详细化学成分。基于多环芳烃的化学活性估算了基线毒性，显然，预测的化学活性不能单独解释毒性增加。然而，随着光降解的进行，包括 O 类和 O 类化合物在内的极性化合物的超高分辨率质谱丰度显著增加。进一步检查化合物的双键等效值表明，具有非芳香和芳香极性结构的极性化合物增加。统计分析表明，增加的极性化合物可以很好地解释增加的毒性。因此，本研究中鉴定的含氧化合物在降解油的毒性中可以发挥重要作用。
