Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Clin Chest Med. 2019 Sep;40(3):573-582. doi: 10.1016/j.ccm.2019.05.012.
Antibody-associated vasculitis comprises 3 small vessel vasculitis syndromes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic polyangiitis (EGPA). This article outlines the major tracheobronchial and pulmonary parenchymal disease manifestations of GPA and MPA and their management, as well as relevant recent advances in the treatment of EGPA. Shared trends in the management of all 3 syndromes are: (1) a focus on glucocorticoid avoidance and (2) an increasing reliance on biologic agents. Evidence from randomized controlled trials and large cohort studies in support of these trends as well as ongoing research efforts are summarized.
抗体相关性血管炎包括 3 种小血管血管炎综合征：肉芽肿性多血管炎（GPA）、显微镜下多血管炎（MPA）和嗜酸性肉芽肿性多血管炎（EGPA）。本文概述了 GPA 和 MPA 的主要气管支气管和肺实质疾病表现及其治疗方法，以及 EGPA 治疗的相关最新进展。所有 3 种综合征的管理有以下共同趋势：（1）注重避免使用糖皮质激素，（2）越来越依赖生物制剂。本文总结了支持这些趋势的随机对照试验和大型队列研究证据，以及正在进行的研究工作。
