D，L-α-二氟甲基鸟氨酸对2,3,7,8-四氯二苯并对二恶英同系物3,3',4,4'-四氯偶氮苯诱发的小鼠胎儿腭裂的影响。

Effect of D,L-alpha-difluoromethyl ornithine on cleft palate induced by the TCDD congener, 3,3',4,4'-tetrachloroazoxybenzene, in the fetuses of mice.

作者信息

Hassoun E A, Arif A T

机构信息

University of Baghdad, Dept. of Toxicology, College of Pharmacy, Iraq.

出版信息

Toxicology. 1988 Sep;51(1):77-85. doi: 10.1016/0300-483x(88)90082-0.

DOI:10.1016/0300-483x(88)90082-0

PMID:3137699

Abstract

The importance of inhibition of ornithine decarboxylase (ODC) activity in murine embryonic tissues for the teratogenic action of the TCDD congener 3,3',4,4'-tetrachloroazoxybenzene (TCAOB), has been studied. When D,L-alpha-difluoromethyl ornithine (DFMO), an inhibitor of ODC activity, was coadministered with TCAOB, it decreased the frequency of cleft palate compared with TCAOB alone. Fetal death induced by TCAOB was not affected by DFMO treatment. It is suggested that the mechanism of cleft palate induced by TCAOB may involve ODC stimulation. However fetal death induced by the latter compound may involve another mechanism, that may not be related to the mechanism of cleft palate induction.

摘要

已对小鼠胚胎组织中鸟氨酸脱羧酶（ODC）活性的抑制对于2,3,7,8-四氯二苯并对二恶英同系物3,3',4,4'-四氯偶氮苯（TCAOB）致畸作用的重要性进行了研究。当ODC活性抑制剂D,L-α-二氟甲基鸟氨酸（DFMO）与TCAOB共同给药时，与单独使用TCAOB相比，它降低了腭裂的发生率。TCAOB诱导的胎儿死亡不受DFMO治疗的影响。提示TCAOB诱导腭裂的机制可能涉及ODC的刺激。然而，后一种化合物诱导的胎儿死亡可能涉及另一种机制，该机制可能与腭裂诱导机制无关。