Hsia M T, Kreamer B L
Toxicol Lett. 1985 Jun;25(3):247-58. doi: 10.1016/0378-4274(85)90204-8.
A delayed wasting syndrome similar to that induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was observed in male Sprague-Dawley rats exposed to 3,3', 4,4'-tetrachloroazoxybenzene (TCAOB) and 3,3',4,4'-tetrachloroazobenzene (TCAB). After a slow growth period, all treatment animals (25 mg/kg, i.p., 2 doses per week) exhibited a starvation-like syndrome characterized by reduced food intake, dramatic loss of body weight and subsequent death. Although the growth of all major organs in the treatment animals was affected, the thymus appeared severely atrophied. The growth kinetics during the earlier phase were further analyzed using serially-killed rats receiving TCAOB. In addition, TCAOB was found to markedly depress the specific activity (mumol/min/g wet liver) of glucose-6-phosphatase, fructose-1,6-bisphosphatase, phosphoenolpyruvate carboxykinase, and pyruvate kinase in the liver. Significant changes in the levels of cytochrome P-450, glutamic-pyruvic transaminase and malic enzyme in the liver were also observed.
在暴露于3,3',4,4'-四氯偶氮苯（TCAOB）和3,3',4,4'-四氯偶氮苯（TCAB）的雄性Sprague-Dawley大鼠中，观察到一种类似于由2,3,7,8-四氯二苯并对二恶英（TCDD）诱导的延迟性消瘦综合征。在经历一段缓慢生长时期后，所有接受治疗的动物（腹腔注射25mg/kg，每周2次）均表现出一种类似饥饿的综合征，其特征为食物摄入量减少、体重急剧下降并随后死亡。尽管接受治疗的动物所有主要器官的生长均受到影响，但胸腺似乎严重萎缩。使用接受TCAOB的系列处死大鼠进一步分析了早期阶段的生长动力学。此外，发现TCAOB可显著降低肝脏中葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶、磷酸烯醇式丙酮酸羧激酶和丙酮酸激酶的比活性（μmol/分钟/克湿肝）。还观察到肝脏中细胞色素P-450、谷丙转氨酶和苹果酸酶水平的显著变化。
