Somade Oluwatobi T, Ajayi Babajide O, Tajudeen Nurudeen O, Atunlute Eniola M, James Adewale S, Kehinde Samuel A
Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Department of Biochemistry, Bowen University, Iwo, Nigeria.
Pathophysiology. 2019 Sep-Dec;26(3-4):305-313. doi: 10.1016/j.pathophys.2019.07.005. Epub 2019 Jul 29.
Consumption of camphor infusions is widely used as an aphrodisiac in preparation for sexual intercourse, to boost performance. There is dearth of information associating or relating its consumption to liver or lung inflammation. Therefore, we investigated the effect of various doses of camphor in an acute study, on hepatic and pulmonary levels of some pro-inflammatory cytokines and chemokines in male wistar rats. Following administration, 2000 and 4000 mg/kg body weight camphor significantly increase liver and lung levels of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6) in a dose dependent manner compared with control, while interleukin 10 (IL-10) levels were significantly increased only by 1000 and 4000 mg/kg body weight camphor in liver and lung respectively, compared with control. Also compared with control, camphor administration resulted in a significant increase in the expressions of hepatic and pulmonary nuclear factor kappa B (NFkB), cyclooxygenase 2 (COX-2), regulated upon activation normal T cell expressed and secreted (RANTES) or CCL5, and monocyte chemo-attractant protein 1 (MCP-1) in a dose dependent manner. It is therefore advised that the use and consumption of camphor should be with caution as it could trigger liver and lung inflammation via activation of NF-kB and up-regulation of pro-inflammatory mediators.
樟脑浸液在准备性交时被广泛用作壮阳药以提高性能力。目前缺乏关于其摄入与肝脏或肺部炎症相关的信息。因此，我们在一项急性研究中调查了不同剂量樟脑对雄性Wistar大鼠肝脏和肺部一些促炎细胞因子及趋化因子水平的影响。给药后，与对照组相比，2000和4000mg/kg体重的樟脑以剂量依赖性方式显著提高肝脏和肺部肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）和白细胞介素6（IL-6）的水平，而白细胞介素10（IL-10）水平仅在肝脏中1000mg/kg体重和肺部中4000mg/kg体重的樟脑作用下与对照组相比显著升高。同样与对照组相比，樟脑给药导致肝脏和肺部核因子κB（NFkB）、环氧化酶2（COX-2）、活化正常T细胞表达和分泌调节因子（RANTES）或CCL5以及单核细胞趋化蛋白1（MCP-1）的表达以剂量依赖性方式显著增加。因此，建议谨慎使用和食用樟脑，因为它可能通过激活NF-κB和上调促炎介质引发肝脏和肺部炎症。
