单次剂量复制子颗粒疫苗对小鼠克里米亚-刚果出血热的异源保护作用。
Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine.
机构信息
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
出版信息
Antiviral Res. 2019 Oct;170:104573. doi: 10.1016/j.antiviral.2019.104573. Epub 2019 Aug 1.
Abstract
No vaccines are currently licensed to prevent Crimean-Congo hemorrhagic fever virus (CCHFV) infection, which can cause mild self-limiting clinical signs or severe, often fatal hemorrhagic fever disease. Here we continued investigations into the utility of a single-dose virus replicon particle (VRP) vaccine regimen by assessing protection against Turkey or Oman strains of CCHFV. We found that all mice were completely protected from disease, supporting broad applicability of this platform for CCHFV prevention.
摘要
目前尚无预防克里米亚-刚果出血热病毒（CCHFV）感染的疫苗获得许可，该病毒可引起轻微的自限性临床症状或严重、常致命的出血热疾病。在这里，我们通过评估对土耳其或阿曼 CCHFV 株的保护作用，继续研究了单价病毒复制子颗粒（VRP）疫苗方案的效用。我们发现所有小鼠均完全免受疾病侵害，这支持了该平台在 CCHFV 预防中的广泛适用性。
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