Abteilung für Plastische, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Regensburg, Regensburg, Germany.
Lehrstuhl für Molekulare und Zelluläre Anatomie, Universität Regensburg, 93053, Regensburg, Germany.
Pflugers Arch. 2019 Sep;471(9):1163-1171. doi: 10.1007/s00424-019-02299-8. Epub 2019 Aug 3.
Sarcomas are characterized by aggressive growth and a high metastasis potentially leading in most cases to a lethal outcome. These malignant tumors of the connective tissue have a high heterogeneity with numerous genetic mutations resulting in more than 100 types of sarcoma that can be grouped into two main kinds: soft tissue sarcoma and bone sarcoma. Sarcomas are often diagnosed at late disease stage, whereas a guaranteed diagnosis of the sarcoma type is fundamental for successful therapy. However, there is no appropriate therapy available. Therefore, the need for new therapies, which prolong survival and improve quality of life, is high. In the last two decades, the role of ion channels in cancer has emerged. Ion channels seem to be an ideal target for anti-tumor therapies. However, different cancer types have their own altered ion channel pattern, and the knowledge about the tumor-associated ion channel expression is fundamental. Here, we focus on the role of different ion channels in sarcoma, their pathophysiology, and possible treatment options.
肉瘤的特征是侵袭性生长和高转移率，这可能导致大多数情况下的致命后果。这些结缔组织的恶性肿瘤具有高度异质性，存在许多基因突变，导致超过 100 种肉瘤类型，可以分为两种主要类型：软组织肉瘤和骨肉瘤。肉瘤通常在疾病晚期才被诊断出来，而保证肉瘤类型的明确诊断对于成功治疗至关重要。然而，目前尚无合适的治疗方法。因此，需要新的治疗方法来延长生存时间并提高生活质量。在过去的二十年中，离子通道在癌症中的作用已经显现出来。离子通道似乎是抗肿瘤治疗的理想靶点。然而，不同的癌症类型有其自身改变的离子通道模式，了解与肿瘤相关的离子通道表达是基础。在这里，我们重点介绍不同离子通道在肉瘤中的作用、它们的病理生理学以及可能的治疗选择。
