School of Chemical Engineering, Guizhou Minzu University, Guiyang 550025, China.
Med Chem. 2020;16(4):431-453. doi: 10.2174/1573406415666190507121744.
Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.
从传统中药苦参、苦参和苦豆子中分离得到的苦参碱类生物碱作为四环喹啉啶类似物，具有多种药理活性，在过去几十年中引起了极大的兴趣。特别是，已经设计和合成了大量的苦参碱衍生物，并对其生物活性进行了研究，近年来不断取得令人鼓舞的结果。这些研究有助于开发更有效的候选药物或治疗剂，并揭示其分子靶点和机制。本文综述了苦参碱类生物碱在 C-13、C-14 或 C-15 位取代、开环、D 环融合和结构简化等方面的生物活性修饰的最新进展。
