Sakaguchi T, Takahashi M, Bray G A
Department of Medicine, School of Medicine, University of Southern California, Los Angeles 90033.
Am J Physiol. 1988 Sep;255(3 Pt 2):R507-12. doi: 10.1152/ajpregu.1988.255.3.R507.
Measurements of sympathetic firing rate have been made after the acute microinjection of glucose or insulin into the lateral hypothalamic area as well as after ablation of this area with locally injected gold thioglucose. Injection of glucose into the lateral hypothalamus (LH) produced a small but significant and dose-dependent reduction in the firing rate of efferent sympathetic nerves to interscapular brown adipose tissue. Injection of insulin into the same region produced a very short-lived increase in efferent sympathetic firing rate. Bilateral lesions in the lateral hypothalamus produced by microinjection and gold thioglucose lowered body weight more than sham injections into the LH of control animals. There was an increase in basal sympathetic firing rate at 3, 9, and 24 h after LH lesions. There was also an increase in firing rate at 1 and 3 days, but by 7 days firing rate had returned to control levels. The data support the hypothesis that LH lesions enhance sympathetic activity but show only very limited modulation by glucose or insulin.
在向外侧下丘脑区域急性微量注射葡萄糖或胰岛素后，以及在用局部注射的金硫葡萄糖损毁该区域后，对交感神经放电频率进行了测量。向外侧下丘脑（LH）注射葡萄糖，可使支配肩胛间棕色脂肪组织的传出交感神经放电频率出现小幅度但显著的剂量依赖性降低。向同一区域注射胰岛素，可使传出交感神经放电频率出现非常短暂的增加。通过微量注射金硫葡萄糖造成的双侧外侧下丘脑损伤，比向对照动物的LH进行假注射更能降低体重。LH损伤后3小时、9小时和24小时，基础交感神经放电频率增加。在1天和3天时放电频率也增加，但到7天时放电频率已恢复到对照水平。这些数据支持这样的假说，即LH损伤会增强交感神经活动，但仅显示出葡萄糖或胰岛素的非常有限的调节作用。
