Arase K, Sakaguchi T, Bray G A
Life Sci. 1987 Aug 3;41(5):657-62. doi: 10.1016/0024-3205(87)90421-8.
The firing rate of efferent sympathetic nerves to brown adipose tissue was measured on 18 h or 18 d following lateral hypothalamic lesions (LH). Eighteen hours following acute lateral hypothalamic lesions, sympathetic firing rate was significantly increased. Following chronic LH lesions there was a decrease in food intake and a fall in body weight which had stabilized by four days. Eleven days after surgery a group of control animals were food restricted and subsequently pair fed twice daily to maintain a body weight comparable to that of the LH lesioned animals. Food intake was lower in the pair-gained animals on all but one day of the experiment. When studied 18 days following LH lesions, sympathetic firing rates were significantly higher than in either the ad lib or pair-fed controls. Sympathetic firing rate in pair fed rats, on the other hand, was significantly lower than in the sham lesioned rats. These data are consistent with the hypothesis that the LH lesion removes an inhibitory control over sympathetic firing rate both acutely and in chronically lesioned animals and that this increased sympathetic firing rate may play an important role in the maintenance of a lower body weight.
在外侧下丘脑损伤（LH）后的18小时或18天，测量了支配棕色脂肪组织的传出交感神经的放电频率。急性外侧下丘脑损伤后18小时，交感神经放电频率显著增加。慢性LH损伤后，食物摄入量减少，体重下降，到第4天时体重趋于稳定。手术后11天，一组对照动物进行食物限制，随后每天分两次配对喂食，以维持与LH损伤动物相当的体重。在实验的除一天之外的所有日子里，配对增重动物的食物摄入量都较低。在LH损伤后18天进行研究时，交感神经放电频率显著高于自由进食或配对喂食的对照组。另一方面，配对喂食大鼠的交感神经放电频率显著低于假损伤大鼠。这些数据与以下假设一致：LH损伤在急性和慢性损伤动物中均消除了对交感神经放电频率的抑制性控制，且这种增加的交感神经放电频率可能在维持较低体重中起重要作用。
