Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Urology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, Italy.
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Department of Urology, European Institute of Oncology, Milan, Italy.
Clin Genitourin Cancer. 2019 Oct;17(5):e1026-e1035. doi: 10.1016/j.clgc.2019.06.003. Epub 2019 Jun 13.
We comprehensively tested contemporary incidence and mortality rates in patients with germ cell tumor of the testis (GCTT).
Within the Surveillance, Epidemiology, and End Results database (2004-2015), statistical analyses included estimated annual percentage changes, multivariable logistic regression (MLR) models, Kaplan-Meier curves, and multivariable Cox regression (MCR) models.
Of 13,114 GCTT patients, 7954 (60.6%) harbored seminoma germ cell tumors of the testis (SGCTT) and 5160 (39.4%) non-SGCTT (NSGCTT). Relative to SGCTT, NSGCTT patients harbored more advanced stage (for stage III 824 [16.0%] vs. 279 patients [3.5%]; P < .001). In MLR, higher rates of stage II/III affected those with never-married status (odds ratio [OR], 1.6; P < .001) and African American ethnicity (OR, 1.5; P = .005) for SGCTT and never-married (OR, 1.3; P = .002) and Hispanic ethnicity (OR, 1.3; P < .001) for NSGCTT. Significant differences in 5-year cancer-specific mortality (CSM) distinguished SGCTT (stage I: 0.4; stage II: 3.4; stage III: 11.4%; P < .001) from NSGCTT (stage I: 1.6; stage II: 2.5; stage III: 22.2%; P < .001). In MCR, unmarried status independently predicted higher CSM for SGCTT (hazard ratio [HR], 2.1; P = .007) and NSGCTT (HR, 1.9; P < .001).
Stage I and stage III NSGCTT survival is worse, than for SGCTT. Never-married, Hispanic, and African American individuals are at higher risk of more advanced stage and/or CSM in SGCTT and NSGCTT.
我们全面测试了睾丸生殖细胞肿瘤（GCTT）患者的当代发病率和死亡率。
在监测、流行病学和最终结果数据库（2004-2015 年）中，统计分析包括估计的年度百分比变化、多变量逻辑回归（MLR）模型、Kaplan-Meier 曲线和多变量 Cox 回归（MCR）模型。
在 13114 例 GCTT 患者中，7954 例（60.6%）为睾丸生殖细胞肿瘤（SGCTT）精原细胞瘤，5160 例（39.4%）为非-SGCTT（NSGCTT）。与 SGCTT 相比，NSGCTT 患者的疾病分期更晚（III 期 824 例[16.0%]，279 例[3.5%]；P<0.001）。在 MLR 中，未婚状态与 II/III 期的更高比例相关，对于 SGCTT 为未婚状态（比值比[OR]，1.6；P<0.001）和非裔美国人种族（OR，1.5；P=0.005），对于 NSGCTT 为未婚状态（OR，1.3；P=0.002）和西班牙裔种族（OR，1.3；P<0.001）。5 年癌症特异性死亡率（CSM）的显著差异区分了 SGCTT（I 期：0.4%；II 期：3.4%；III 期：11.4%；P<0.001）和 NSGCTT（I 期：1.6%；II 期：2.5%；III 期：22.2%；P<0.001）。在 MCR 中，未婚状态独立预测 SGCTT（危险比[HR]，2.1；P=0.007）和 NSGCTT（HR，1.9；P<0.001）的 CSM 更高。
I 期和 III 期 NSGCTT 的生存率比 SGCTT 差。未婚、西班牙裔和非裔美国人在 SGCTT 和 NSGCTT 中处于更晚期和/或 CSM 的风险更高。
