National Center for Chronic and Non-communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China.
Biomed Environ Sci. 2021 Feb 20;34(2):152-162. doi: 10.3967/bes2021.021.
Testicular germ cell tumors (TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.
The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of TGCT.
Black males were diagnosed at a later stage, more commonly with local or distant metastases. The incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival (OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting mortality.
Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.
睾丸生殖细胞肿瘤（TGCT）是 15 至 39 岁男性中最常见的癌症。先前的研究已经考虑了与 TGCT 存活率和种族/民族有关的因素，但尚未彻底评估诊断出的癌症的组织学类型。
该数据来自 1992 年至 2015 年期间 42854 名符合条件的患者，这些患者来自监测、流行病学和最终结果 18。确定了每种协变量的精原细胞瘤和非精原细胞瘤亚型的频率和列百分比。我们使用 Cox 比例风险回归来评估多种因素对 TGCT 诊断后死亡率的影响。
黑人男性的诊断阶段较晚，更常见局部或远处转移。黑人非精原细胞瘤肿瘤的 TGCT 发病率增长最为显著。不同种族和组织学亚型之间的生存率差异，非精原细胞瘤患者的总体生存率（OS）明显差于精原细胞瘤患者。死亡的最重要定量预测因子是诊断时的阶段，诊断年龄较大也是影响死亡率的重要因素。
睾丸生殖细胞肿瘤的组织学类型是决定不同种族男性睾丸癌预后的重要因素。
