预测接受扁桃体鳞状细胞癌放疗的患者颌骨不同区域的辐射剂量分布。
Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil.
机构信息
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Weill Cornell Medical College, Cornell University, New York, New York.
出版信息
Head Neck. 2019 Oct;41(10):3604-3611. doi: 10.1002/hed.25883. Epub 2019 Aug 5.
BACKGROUND
Radiotherapy (RT), the main treatment for patients with head and neck cancer, can lead to dental complications.
METHODS
We identified 244 patients with squamous cell carcinoma of the tonsil treated with RT from 2004 to 2013. For each patient, we contoured the 10 tooth-bearing regions and calculated the radiation dose (gray, Gy) to each region. From this data set, we built two predictive models to determine the expected maximum radiation dose, one for the non-molar regions and another for the molar regions.
RESULTS
For the non-molars, the final model included location, T-classification, and overall stage, with a median absolute prediction error of 7.0 Gy. For the molars, the final model included location, T-classification, overall stage, and treatment year, with a median absolute error of 6.0 Gy.
CONCLUSIONS
Our current model offers a good estimation of the maximum radiation dose delivered to different regions of the jaw; future work will independently validate these models.
背景
放射治疗（RT）是头颈部癌症患者的主要治疗方法，但会导致牙科并发症。
方法
我们从 2004 年至 2013 年确定了 244 例接受 RT 治疗的扁桃体鳞状细胞癌患者。对于每个患者，我们描绘了 10 个有牙齿的区域，并计算了每个区域的辐射剂量（戈瑞，Gy）。从这个数据集，我们构建了两个预测模型来确定预期的最大辐射剂量，一个用于非磨牙区域，另一个用于磨牙区域。
结果
对于非磨牙，最终模型包括位置、T 分类和总分期，中位数绝对预测误差为 7.0Gy。对于磨牙，最终模型包括位置、T 分类、总分期和治疗年份，中位数绝对误差为 6.0Gy。
结论
我们目前的模型可以很好地估计颌骨不同区域接受的最大辐射剂量；未来的工作将独立验证这些模型。
Zotero 插件