Singh Annu, Huryn Joseph M, Kronstadt Kenneth L, Yom SaeHee K, Randazzo Joseph R, Estilo Cherry L
Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Front Oral Health. 2022 Jul 28;3:980786. doi: 10.3389/froh.2022.980786. eCollection 2022.
Osteoradionecrosis (ORN) of the jaw is one of the most dreaded complications of head and neck radiation therapy. Despite the evolution of radiation treatment modalities, ORN continues to remain a therapeutic challenge and its etiopathogenesis still remains unclear. It is clinically characterized by exposed necrotic bone within the head and neck radiation field. Over the past years, several studies have reported on the definition, staging, incidence, etiology, and management of this oral complication. In this review, we summarize the literature on ORN and discuss our institutional experience and management strategies that aim to predict and mitigate risk for ORN.
颌骨放射性骨坏死(ORN)是头颈部放射治疗最可怕的并发症之一。尽管放射治疗方式不断演变,但ORN仍然是一个治疗难题,其病因发病机制仍不清楚。其临床特征为头颈部放射野内暴露的坏死骨。在过去几年中,已有多项研究报道了这种口腔并发症的定义、分期、发病率、病因及治疗。在本综述中,我们总结了关于ORN的文献,并讨论了我们机构旨在预测和降低ORN风险的经验及管理策略。