Hirschman S Z, Meyers B R, Bradbury K, Mehl B, Gendelman S, Kimelblatt B
Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York 10029.
Arch Intern Med. 1988 Sep;148(9):2001-7.
A comprehensive control program for utilization of anti-microbial agents in a large tertiary university teaching hospital regulates both dosage and duration of therapy and requires the prior approval of an infectious disease specialist for utilization of restricted antimicrobial agents. Benefits of the program include more cost-effective antimicrobial therapy and increased physician education in the use of these drugs. Gross savings in pharmacy costs for antibiotics during the first year of the program (1985) amounted to +483,032 for an average monthly savings of +40,252. Gross savings for 1986 were +211,786 with monthly savings of +17,648. The control of the use of one agent may lead to overuse of another agent. Antimicrobial prescribing patterns of physicians are quickly influenced by changing regulations of the program. An ongoing surveillance and review program of in-hospital utilization of antimicrobial agents is necessary to maintain effective and flexible controls.
一所大型三级大学教学医院实施的抗菌药物使用综合控制项目，对治疗的剂量和疗程都进行规范，并且使用受限抗菌药物需要事先获得传染病专家的批准。该项目的益处包括更具成本效益的抗菌治疗以及增加医生在使用这些药物方面的培训。在项目的第一年（1985年），抗生素药房成本的总节省额达到483,032美元，平均每月节省40,252美元。1986年的总节省额为211,786美元，每月节省17,648美元。对一种药物使用的控制可能会导致另一种药物的过度使用。医生的抗菌药物处方模式会迅速受到项目不断变化的规定的影响。有必要持续开展医院内抗菌药物使用的监测和审查项目，以维持有效且灵活的控制。
