Kunochova I, Papcun P, Krizko M, Gabor M, Alfoldi M, Ferianec V
Bratisl Lek Listy. 2019;120(8):563-565. doi: 10.4149/BLL_2019_091.
Analyzing the clinical group to evaluate current indications for cordocenteses, their complications and data obtained in further pregnancy management.
Retrospective analysis evaluated 92 cordocenteses (diagnostic and therapeutic) performed during the period of 2007‒2018. These were performed between 17 and 36 weeks of gestation under ultrasound guidance by a specialist at 2nd Department of Gynecology and Obstetrics, Faculty of Medicine, Comenius University.
Out of 92 procedures, 78 were diagnostic and 14 were therapeutic. The diagnostic cordocentesis was successful in 97.4 % and intrauterine therapy was successful in 85.7 %. There were 2 (2.56 %) diagnostic cordocenteses complicated by fetal demise and 2 (14 %) intrauterine demises in therapeutic cordocentesis. The pathological karyotype was detected in 14.5 %. Aneuploidia was present in 4 cases (44.4 %), mosaicism in 4 cases (44.4 %) and triploidia in one case (11.1 %).
Despite of novel molecular genetic technique cordocentesis still plays unreplaceable role in current prenatal diagnosis and treatment. The risk of complications of cordocentesis increases depending on the severity of fetal pathology in pathologic pregnancies. In some situations it can be used as a useful tool for original fetal diagnosis and therapy (Tab. 3, Ref. 20).
分析临床病例组，以评估目前进行脐带穿刺术的指征、其并发症以及在后续妊娠管理中获得的数据。
回顾性分析评估了2007年至2018年期间进行的92例脐带穿刺术（诊断性和治疗性）。这些手术由夸美纽斯大学医学院妇产科第二科室的一名专家在超声引导下于妊娠17至36周期间进行。
在92例手术中，78例为诊断性手术，14例为治疗性手术。诊断性脐带穿刺术成功率为97.4%，宫内治疗成功率为85.7%。诊断性脐带穿刺术中有2例（2.56%）并发胎儿死亡，治疗性脐带穿刺术中有2例（14%）发生宫内死亡。病理核型检出率为14.5%。非整倍体4例（44.4%），嵌合体4例（44.4%），三倍体1例（11.1%）。
尽管有新的分子遗传学技术，脐带穿刺术在目前的产前诊断和治疗中仍发挥着不可替代的作用。脐带穿刺术的并发症风险根据病理性妊娠中胎儿病变的严重程度而增加。在某些情况下，它可用作最初胎儿诊断和治疗的有用工具（表3，参考文献20）。
