suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1.

The current study aimed to explore the function of on the progression of oral squamous cell carcinoma (OSCC) and relevant molecular mechanisms. Expression profile of in OSCC tissues and cells was detected using quantitative real-time polymerase chain reaction (qRT-PCR) method. Chi-square test was performed to estimate the relationship between and clinical parameters of OSCC cases. Cell viability and motility abilities were estimated using MTT and transwell assays, respectively. Potential targets of in OSCC were identified through bioinformatics analysis and luciferase reporter assay. exhibited decreased expression in OSCC tissues and cells, compared to non-cancerous controls ( < .05 for both). Moreover, its down-regulation was closely correlated with lymph node metastasis ( = .044) and TNM stages ( = .001). Enforced expression reduced cell proliferation, migration and invasion, while its knockdown exhibited opposite effects. Phospholipase D1 () was confirmed as a target of in OSCC. could inhibit wnt/β-catenin pathway through targeting , thus realizing its anti-tumour action in OSCC. may be a tumour suppressor in OSCC by targeting /Wnt/β-catenin pathway.