McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Department of Community and Environmental Health, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
J Toxicol Environ Health B Crit Rev. 2019;22(7-8):264-287. doi: 10.1080/10937404.2019.1642593. Epub 2019 Aug 4.
A database on mechanistic characteristics of human carcinogenic agents was developed by collecting mechanistic information on agents identified as human carcinogens (Group 1) by the International Agency for Research on Cancer (IARC) in the . A two-phase process is described for the construction of the database according to 24 toxicological endpoints, derived from appropriate test systems that were acquired from data obtained from the mechanisms sections of the IARC Monographs (Section 4) and a supplementary PubMed search. These endpoints were then aligned with 10 key characteristics of human carcinogens that reflect the broader attributes of these agents relating to the development of cancer in humans. The considerations involved in linking of toxicological endpoints to key characteristics are described and specific examples of the determination of key characteristics for six specific agents (tamoxifen, hepatitis B virus, arsenic, ultraviolet and solar radiation, tobacco smoking, and dioxin) are provided. Data for humans and animals were tabulated separately, as were results for and for sources of information. The database was constructed to support a separate analysis of the expression of these endpoints by 86 Group 1 carcinogens, and along with an analysis of the key characteristics of these agents.
建立了一个人类致癌剂机制特征数据库，通过收集国际癌症研究机构（IARC）确定的人类致癌物（第 1 组）的机制信息来完成。根据从 IARC 专论（第 4 节）的机制部分和补充的 PubMed 搜索中获得的数据，描述了一个适用于 24 个毒理学终点的数据库构建的两阶段过程，这些终点源自适当的测试系统。这些终点随后与反映这些与人类癌症发生相关的更广泛属性的人类致癌物的 10 个关键特征相匹配。描述了将毒理学终点与关键特征联系起来的考虑因素，并提供了六个特定物质（三苯氧胺、乙型肝炎病毒、砷、紫外线和太阳辐射、吸烟和二恶英）确定关键特征的具体示例。数据按人类和动物分别列出，按 和 信息来源列出结果。该数据库的构建旨在支持对 86 种第 1 组致癌物、 以及这些物质的关键特征的这些终点的单独分析。
