人类致癌物的生物学机制概述。
Overview of biological mechanisms of human carcinogens.
机构信息
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
出版信息
J Toxicol Environ Health B Crit Rev. 2019;22(7-8):288-359. doi: 10.1080/10937404.2019.1643539. Epub 2019 Oct 20.
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
本综述总结了国际癌症研究机构（IARC）第 106 卷中确定的 109 种 1 类人类致癌物的致癌机制，这些物质被认为是人类癌症的病因。IARC 采用经过充分验证的证据权重方法，评估人类、实验和机制证据，以评估可疑致癌物质。该专论详细介绍了所有致癌物的机制信息。具有相似作用机制（例如，发射α粒子的物质）的致癌物被组合成组进行综述。根据 IARC 专论中的信息，主要以信息为基础，辅以非系统性综述，对 86 种致癌物或致癌物组的机制概况进行了叙述性总结。大多数致癌物包含遗传毒性机制。
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