Oren Noga, Ash Elissa L, Shapira-Lichter Irit, Elkana Odelia, Reichman-Eisikovits Osnat, Chomsky Lior, Lerner Yulia
Functional MRI Center, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Front Aging Neurosci. 2019 Jul 16;11:163. doi: 10.3389/fnagi.2019.00163. eCollection 2019.
Memory decline is a feature of some, but not all, healthy older adults. The neural patterns of this variability are still largely unknown. We examined the resting-state functional connectivity (RSFC) of older and younger adults before and after cognitive effort as an underlying feature for subsequent memory changes, focusing on the RSFC between the left anterior hippocampus (laHC) and the posterior hippocampi (pHC). Results showed that for younger adults, post-effort increases in laHC-pHC RSFC were related to increases in RSFC between the laHC and the hubs of the default mode network (DMN). However, for older adults, post-effort increases in the RSFC of laHC-pHC were related to decreases in the RSFC of the laHC and right precentral gyrus. Thus, the correlation between intra-HC and inter-HC RSFC was altered with cognitive effort and aging. Importantly, older adults who had lower post-effort RSFC between the laHC and the pHC demonstrated a decline in episodic memory 2 years later. Hence, the change in intra-HC RSFC following cognitive effort was able to predict subsequent memory function with aging in our sample.
记忆衰退是部分（而非全部）健康老年人的一个特征。这种变异性的神经模式在很大程度上仍然未知。我们研究了年轻人和老年人在认知努力前后的静息态功能连接（RSFC），将其作为后续记忆变化的一个潜在特征，重点关注左前海马体（laHC）和后海马体（pHC）之间的RSFC。结果显示，对于年轻人，努力后laHC - pHC RSFC的增加与laHC和默认模式网络（DMN）枢纽之间RSFC的增加有关。然而，对于老年人，努力后laHC - pHC RSFC的增加与laHC和右侧中央前回RSFC的减少有关。因此，随着认知努力和衰老，海马体内和海马体间RSFC的相关性发生了改变。重要的是，laHC和pHC之间努力后RSFC较低的老年人在两年后情景记忆出现衰退。因此，在我们的样本中，认知努力后海马体内RSFC的变化能够预测衰老过程中后续的记忆功能。
