Beau J
Groupe Génétique, Neurogénétique et Comportement, Université Paris-V, U.E.R. Biomédicale, Paris.
C R Acad Sci III. 1988;307(2):37-40.
Rhythm of activity in inbred strains of mice in synchronic LD 12:12 was shown to be characterized by six indices: amount of activity, circadian level, pulsatile activity, ratio of nocturnal/diurnal activity, and two temporal frequency descriptors. Genetic analysis of rhythm of activity was conducted on parental strains C57BL/6By and BALB/cBy via the reciprocal F1s and the seven recombinant inbred lines. No maternal effect for the reciprocal F1s was observed. The findings indicate dominance and heterosis effects for the F1s. Heterosis tends towards a better fit of rhythm to natural day/night synchrony. RI findings eliminate the hypothesis of monogenetic correlates for all six parameters investigated, and in conjunction with the F1 analysis demonstrate that each indices have polygenic correlates with at least one different locus for each of the measures of activity.
在同步的12:12光照/黑暗周期下，近交系小鼠的活动节律表现为六个指标：活动量、昼夜水平、搏动性活动、夜间/白天活动比率以及两个时间频率描述符。通过正反交F1代和七个重组近交系，对亲本C57BL/6By和BALB/cBy品系的活动节律进行了遗传分析。未观察到正反交F1代的母体效应。研究结果表明F1代存在显性和杂种优势效应。杂种优势倾向于使节律更好地适应自然昼夜同步。重组近交系的研究结果排除了所研究的所有六个参数的单基因相关性假设，并且与F1分析一起表明，每个指标都具有多基因相关性，每个活动测量指标至少有一个不同的基因座。
