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[Functional interaction between the tumor necrosis factor and interleukin 2 during induction of lymphokine activated killer cytotoxic activity].

作者信息

Blay J Y, Bertoglio J, Gay F, Fradelizi D, Chouaib S

机构信息

Laboratoire d'Immunologie, U.A. n 1156, C.N.R.S., Institute Gustave-Roussy, Villejuif.

出版信息

C R Acad Sci III. 1988;307(2):47-51.

PMID:3138005
Abstract

TNF has a differential effect on the induction of LAK activity which is dependent on the IL-2 concentrations used for LGL stimulation. TNF was found to synergize with low concentrations of IL-2 which are normally ineffective in inducing LAK activity. When IL-2 was used at concentrations optimal for LAK generation, TNF did not further enhance the differentiation of LGL into LAK effectors. When anti-TNF was included in the 51Cr-release assay, no effect on the cytolytic activity was observed. We also demonstrate that IL-2 induced an increase of specific TNF binding to LGL.

摘要

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