Zeng Z, Si C W, Yu M
Department of Infectious Diseases, First Teaching Hospital, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1994 Apr;74(4):235-7, 256.
We studied the effect of single or combination of interleukin-2 (IL-2), interleukin-4 (IL-4) and tumor necrosis factor (TNF) on lymphokine-activated killer cells (LAK) activity which killed both of target cells HepG2 and 2 2,1,5 cells induced for seven days. It was shown that LAK activity induced by the combination of triplet of IL-2, IL-4 and TNF was higher than that induced by single or two of IL-2, IL-4 and TNF, and that enhanced LAK activity was associated with the quantity of IL-2 receptor expression and lysosomes of LAK precursors.
我们研究了白细胞介素-2（IL-2）、白细胞介素-4（IL-4）和肿瘤坏死因子（TNF）单独使用或联合使用对淋巴因子激活的杀伤细胞（LAK）活性的影响，该杀伤细胞可杀伤两种经诱导7天的靶细胞HepG2和22,1,5细胞。结果表明，IL-2、IL-4和TNF三联体联合诱导的LAK活性高于IL-2、IL-4和TNF单独或两者联合诱导的活性，且增强的LAK活性与LAK前体细胞的IL-2受体表达量和溶酶体有关。
