Reddy Raju, Verma Nupur, Mohammed Tan-Lucien
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Florida, 1600 SW Archer Rd, P.O. Box 100225, Gainesville, FL, USA.
Department of Radiology, University of Florida, 1600 SW Archer Rd, P.O. Box 100374, Gainesville, FL, USA.
Case Rep Pulmonol. 2019 Jul 14;2019:1934695. doi: 10.1155/2019/1934695. eCollection 2019.
Florida red tides occur annually due to proliferation of the marine dinoflagellate , which produces neurotoxins known as brevotoxins. Inhalational exposure to brevotoxins usually results in upper airway symptoms only. Rarely does exposure lead to lower respiratory tract symptoms as in our case. We report a case of a 50-year-old man who presented with a 4-week history of dyspnea after exposure to the red tide. Computed tomography (CT) of the chest showed diffuse bilateral ground glass opacities and interstitial thickening. Bronchoalveolar lavage cultures and cytology were negative. The patient was started on steroids. Over the next few weeks, the patient's symptoms resolved. Repeat CT chest showed complete resolution of the ground glass opacities. Steroids were then tapered. Most patients who are exposed to algal blooms have self-limiting symptoms. Patients with asthma are particularly susceptible to worsening respiratory symptoms after exposure to brevotoxin aerosols. This case highlights that, in rare cases, exposure to red tide can results in severe lower respiratory tract symptoms.
佛罗里达赤潮每年都会发生,这是由于海洋双鞭毛藻大量繁殖所致,这种藻类会产生一种名为短裸甲藻毒素的神经毒素。吸入短裸甲藻毒素通常只会导致上呼吸道症状。像我们这个病例这样,接触毒素后导致下呼吸道症状的情况很少见。我们报告一例50岁男性病例,该患者在接触赤潮后出现了为期4周的呼吸困难病史。胸部计算机断层扫描(CT)显示双侧弥漫性磨玻璃影和间质增厚。支气管肺泡灌洗培养和细胞学检查均为阴性。患者开始使用类固醇治疗。在接下来的几周里,患者的症状得到缓解。胸部CT复查显示磨玻璃影完全消失。随后逐渐减少类固醇用量。大多数接触藻华的患者症状会自行缓解。哮喘患者在接触短裸甲藻毒素气溶胶后,呼吸道症状尤其容易加重。该病例突出表明,在极少数情况下,接触赤潮会导致严重的下呼吸道症状。