Kirkpatrick Barbara, Fleming Lora E, Bean Judy A, Nierenberg Kate, Backer Lorraine C, Cheng Yung Sung, Pierce Richard, Reich Andrew, Naar Jerome, Wanner Adam, Abraham William M, Zhou Yue, Hollenbeck Julie, Baden Daniel G
Mote Marine Laboratory, Sarasota, Florida, 34236.
Harmful Algae. 2011 Jan 1;10(2):138-143. doi: 10.1016/j.hal.2010.08.005.
Blooms of the toxic dinoflagellate, Karenia brevis, produce potent neurotoxins in marine aerosols. Recent studies have demonstrated acute changes in both symptoms and pulmonary function in asthmatics after only 1 hour of beach exposure to these aerosols. This study investigated if there were latent and/or sustained effects in asthmatics in the days following the initial beach exposure during periods with and without an active Florida red tide.Symptom data and spirometry data were collected before and after 1 hour of beach exposure. Subjects kept daily symptom diaries and measured their peak flow each morning for 5 days following beach exposure. During non-exposure periods, there were no significant changes in symptoms or pulmonary function either acutely or over 5 days of follow-up. After the beach exposure during an active Florida red tide, subjects had elevated mean symptoms which did not return to the pre-exposure baseline for at least 4 days. The peak flow measurements decreased after the initial beach exposure, decreased further within 24 hours, and continued to be suppressed even after 5 days. Asthmatics may continue to have increased symptoms and delayed respiratory function suppression for several days after 1 hour of exposure to the Florida red tide toxin aerosols.
有毒的短裸甲藻大量繁殖时，会在海洋气溶胶中产生强效神经毒素。最近的研究表明，哮喘患者在海滩接触这些气溶胶仅1小时后，症状和肺功能就会出现急性变化。本研究调查了在佛罗里达红潮活跃期和非活跃期，哮喘患者在初次海滩接触后的数天内是否存在潜在和/或持续影响。在海滩接触1小时前后收集症状数据和肺活量测定数据。受试者记录每日症状日记，并在海滩接触后的5天里每天早晨测量其峰值流速。在非接触期，无论是急性还是在5天的随访期内，症状或肺功能均无显著变化。在佛罗里达红潮活跃期进行海滩接触后，受试者的平均症状升高，至少4天未恢复到接触前的基线水平。初次海滩接触后峰值流速测量值下降，在24小时内进一步下降，甚至在5天后仍持续受到抑制。哮喘患者在接触佛罗里达红潮毒素气溶胶1小时后，可能会在数天内持续出现症状加重和呼吸功能抑制延迟的情况。
