Mohammed Danahe, Versaevel Marie, Bruyère Céline, Alaimo Laura, Luciano Marine, Vercruysse Eléonore, Procès Anthony, Gabriele Sylvain
Mechanobiology and Soft Matter Group, Interfaces and Complex Fluids Laboratory, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Department of Neurosciences, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Front Bioeng Biotechnol. 2019 Jul 16;7:162. doi: 10.3389/fbioe.2019.00162. eCollection 2019.
Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due to their critical localization at the cell-ECM interface, transmembrane integrins are mediators of bidirectional signaling, playing a key role in "outside-in" and "inside-out" signal transduction. After presenting the basic conceptual fundamentals related to cell mechanobiology, we review the current state-of-the-art technologies that facilitate the understanding of mechanotransduction signaling pathways. Finally, we highlight innovative technological developments that can help to advance our understanding of the mechanisms underlying nuclear mechanotransduction.
细胞和组织可以通过基于整合素的黏附位点感知细胞外环境（ECM）物理化学性质的变化，并在一个称为机械转导的过程中调整其生理反应。由于跨膜整合素在细胞-ECM界面的关键定位，它们是双向信号传导的介质，在“由外向内”和“由内向外”信号转导中发挥关键作用。在介绍了与细胞机械生物学相关的基本概念基础之后，我们回顾了有助于理解机械转导信号通路的当前最先进技术。最后，我们强调了创新技术发展，这些发展有助于推进我们对核机械转导潜在机制的理解。
