白塞病患者的脂蛋白胆固醇浓度

Lipoprotein cholesterol concentrations in patients with Behçet's disease.

作者信息

Mitamura T, Ohno S, Ariga H, Ohsaka T, Iwasaki N, Matsuda H, Matsumiya H

机构信息

Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

Clin Chim Acta. 1988 Jul 29;175(3):277-83. doi: 10.1016/0009-8981(88)90103-9.

DOI:10.1016/0009-8981(88)90103-9

PMID:3138049

Abstract

Serum cholesterol concentrations among very low, low, and high density lipoproteins (VLDL, LDL and HDL) in 12 male patients with Behçet's disease were compared with those of 12 normal male subjects. Serum lipoproteins were separated by a combination of ultracentrifugation and gel filtration chromatography. The patients had significantly (p less than 0.001) lower concentrations of HDL-cholesterol than the control subjects (356 +/- 62 mg/l vs. 573 +/- 108 mg/l, means +/- SD). The cholesterol concentrations in apolipoprotein B-containing lipoproteins (VLDL and LDL) from the patients tended to be reciprocally higher than those of the controls, though not statistically significant. There was no difference in serum total cholesterol concentrations. The chemical composition of HDL from the patient group was characterized by higher protein and lower cholesterol (both esterified and free) contents compared with the control HDL.

摘要

将12例白塞病男性患者极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）中的血清胆固醇浓度与12名正常男性受试者的血清胆固醇浓度进行了比较。血清脂蛋白通过超速离心和凝胶过滤色谱法相结合的方法进行分离。患者的HDL胆固醇浓度显著低于对照组（p<0.001）（356±62mg/l对573±108mg/l，均值±标准差）。患者含载脂蛋白B的脂蛋白（VLDL和LDL）中的胆固醇浓度往往比对照组高，尽管无统计学意义。血清总胆固醇浓度无差异。与对照组HDL相比，患者组HDL的化学组成特点是蛋白质含量较高，胆固醇（酯化和游离）含量较低。