Tursen Umit, Eskandari Gulcin, Kaya Tamer Irfan, Tamer Lulufer, Ikizoglu Guliz, Atik Ugur
Department of Dermatology, University of Mersin School of Medicine, Mersin, Turkey.
Int J Dermatol. 2004 Dec;43(12):900-3. doi: 10.1111/j.1365-4632.2004.02020.x.
Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD.
In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects.
Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant.
The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.
白塞病（BD）是一种病因不明的多系统疾病，其特征为慢性复发性口腔生殖器溃疡和葡萄膜炎。BD患者存在一些脂蛋白代谢异常。
本研究将30例BD患者的载脂蛋白E（apo E）多态性和脂蛋白胆固醇浓度与27例对照者进行比较。
患者和对照者血脂均正常。BD患者的高密度脂蛋白（HDL）胆固醇浓度显著高于对照者（P < 0.05）；然而，血清甘油三酯、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）胆固醇浓度无差异。两组apo E基因型和等位基因的分布相同。两组之间等位基因频率存在细微差异，但无统计学意义。
我们的患者中观察到的高HDL胆固醇水平与apo E等位基因异常无关。
