Kreft Alexander, Ehlers Stephanie, Jones Peter G, Werz Daniel B
Org Lett. 2019 Aug 16;21(16):6315-6319. doi: 10.1021/acs.orglett.9b02197. Epub 2019 Aug 5.
Donor-acceptor (D-A) cyclobutanes with two geminal ester groups as acceptors are reacted with electron-rich arenes as nucleophiles to afford ring-opened products. AlCl mediates this Friedel-Crafts-type reaction. A variety of donors and electron-rich arenes are used. Nucleophilic thiols and selenols also trigger this ring-opening reaction. Furthermore, a comparison of various physical parameters has been carried out for several D-A cyclobutanes.
以两个偕二酯基作为受体的给体-受体（D-A）环丁烷与作为亲核试剂的富电子芳烃反应，得到开环产物。AlCl介导这种傅克型反应。使用了多种给体和富电子芳烃。亲核硫醇和硒醇也能引发这种开环反应。此外，还对几种D-A环丁烷的各种物理参数进行了比较。
