一锅法金（III）/路易斯酸催化硝基炔烃的环异构化反应以及与给体-受体环丙烷的[3+3]环加成反应
One-Pot Au[III]-/Lewis Acid Catalyzed Cycloisomerization of Nitroalkynes and [3 + 3]Cycloaddition with Donor-Acceptor Cyclopropanes.
作者信息
Dhote Pawan S, Ramana Chepuri V
机构信息
Division of Organic Chemistry , CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road , Pune 411 008 , India.
Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan, 2 Rafi Marg , New Delhi 110002 , India.
出版信息
Org Lett. 2019 Aug 16;21(16):6221-6224. doi: 10.1021/acs.orglett.9b02035. Epub 2019 Aug 5.
PMID:31380649
Abstract
A one-pot protocol for the synthesis of a tricyclic pseudoindoxyl scaffold from 2-nitroalkynylbenzenes, comprising of an Au(III)-catalyzed nitroalkyne cycloisomerization leading to isatogen and its [3 + 3]-cycloaddition with donor-acceptor cyclopropanes mediated by a suitable Lewis acid, has been developed.
摘要
已开发出一种由2-硝基炔基苯合成三环假吲哚支架的一锅法方案，该方案包括金（III）催化的硝基炔环异构化生成异吲哚酮，以及由合适的路易斯酸介导的其与供体-受体环丙烷的[3+3]环加成反应。
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