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澳大利亚昆士兰州院外 ST 段抬高型心肌梗死(STEMI):全州院前再灌注策略 11 年的研究结果。

Prehospital ST-Segment Elevation Myocardial Infarction (STEMI) in Queensland, Australia: Findings from 11 Years of the Statewide Prehospital Reperfusion Strategy.

出版信息

Prehosp Emerg Care. 2020 May-Jun;24(3):326-334. doi: 10.1080/10903127.2019.1651433. Epub 2019 Aug 23.

Abstract

Field identification and treatment of ST-segment elevation myocardial infarction (STEMI) by paramedics is an important component of the continuum of care for these patients. This study described real-world clinical practice in prehospital management of STEMI patients in Queensland, Australia. Retrospective analysis of data sourced from the STEMI database of the Queensland Ambulance Service, Australia. Adult STEMI patients identified by paramedics between February 2008 and December 2018 in Queensland were included. Key aspects of prehospital STEMI care were described. Clinically-important time intervals from symptom onset to reperfusion were reported. A total of 8,388 patients were included. The proportion of patients receiving prehospital reperfusion treatment has improved markedly, increasing from 34% in 2008 to 65% in 2018 ( < 0.001). Direct referral of patients to a hospital for primary percutaneous coronary intervention (pPCI), and administration of preparatory antiplatelet and anticoagulant medications, was the main reperfusion treatment pathway, accounting for 75% of patients receiving reperfusion treatment. Time from paramedic arrival at scene to first 12-lead electrocardiogram has significantly reduced, from 11 minutes in 2008 to 6 minutes from 2012 onwards ( < 0.001). Median (interquartile range, IQR) time from prehospital STEMI identification to reperfusion was 88 (74-103) minutes for patients referred by paramedics to a hospital for pPCI. Fifty-five percent of patients who underwent pPCI achieved time from STEMI identification to reperfusion within 90 minutes. For patients receiving prehospital fibrinolysis, median (IQR) time from STEMI identification to administration of a fibrinolytic agent was 21 (12-33) minutes. The implementation of a statewide prehospital reperfusion strategy has markedly improved the rate of prehospital reperfusion treatment and key time metrics. Ongoing quality improvement efforts are required to further reduce delays in reperfusion.

摘要

急救人员对 ST 段抬高型心肌梗死(STEMI)的现场识别和治疗是此类患者连续护理的重要组成部分。本研究描述了澳大利亚昆士兰州院前管理 STEMI 患者的真实临床实践。这是对澳大利亚昆士兰救护车服务 STEMI 数据库中数据的回顾性分析。纳入了 2008 年 2 月至 2018 年 12 月期间由急救人员识别的成年 STEMI 患者。描述了 STEMI 院前护理的关键方面。报告了从症状发作到再灌注的临床重要时间间隔。共纳入 8388 例患者。接受院前再灌注治疗的患者比例明显提高,从 2008 年的 34%增加到 2018 年的 65%(<0.001)。直接将患者转诊至医院行直接经皮冠状动脉介入治疗(pPCI),以及给予预备性抗血小板和抗凝药物,是主要的再灌注治疗途径,占接受再灌注治疗患者的 75%。从急救人员到达现场到首次 12 导联心电图的时间显著缩短,从 2008 年的 11 分钟缩短至 2012 年以后的 6 分钟(<0.001)。由急救人员转诊至医院行 pPCI 的患者,从院前 STEMI 识别到再灌注的中位(四分位间距,IQR)时间为 88(74-103)分钟。55%接受 pPCI 的患者实现了 STEMI 识别至再灌注时间在 90 分钟内。接受院前溶栓治疗的患者,从 STEMI 识别到溶栓药物给药的中位(IQR)时间为 21(12-33)分钟。全州范围的院前再灌注策略的实施显著提高了院前再灌注治疗率和关键时间指标。需要持续进行质量改进工作以进一步减少再灌注延迟。

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