Hamamci Mehmet, Tombul Temel
Department of Neurology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. E-mail:
Neurosciences (Riyadh). 2019 Jul;24(3):185-191. doi: 10.17712/nsj.2019.3.20190004.
To demonstrate the importance of visual evoked potential (VEP) in determining the severity and prognosis of the disease and in monitoring the clinical course in patients with idiopathic intracranial hypertension (IIH).
This is a prospective cross-sectional study conducted covering the period between March 2014 and January 2015. The study included 32 patients recently diagnosed with IIH and 30 healthy volunteers. The initial VEP values of the IIH patients were compared to the VEP values of the healthy control group. Furthermore, the initial VEP values of the IIH patients were compared with their VEP values after one month of treatme RESULTS: The mean age of the IIH patients was 37.8+/-12.02 years. Of the IIH patients, 27 (84%) were females and 5 (16%) were males. There was a statistically significant association of the initial VEP values with the visual field findings (p=0.011) and visual acuity (p=0.040). Moreover, a statistically significant difference was found between the control group and IIH patients in terms of right (p less than 0.001) and left P100 values (p less than 0.001). While 18 (56%) of the initial VEPs of IIH patients were pathological, 14 (44%) of the second VEPs were pathological, and this difference was not statistically significant (p=0.125).
A relationship between the VEP P100 values and the severity of the disease was detected, while the importance of monitoring VEP values in the follow-up of IIH patients was not demonstrated.
证明视觉诱发电位(VEP)在确定特发性颅内高压(IIH)患者疾病严重程度和预后以及监测临床病程中的重要性。
这是一项前瞻性横断面研究,涵盖2014年3月至2015年1月期间。该研究纳入了32例最近诊断为IIH的患者和30名健康志愿者。将IIH患者的初始VEP值与健康对照组的VEP值进行比较。此外,将IIH患者的初始VEP值与其治疗一个月后的VEP值进行比较。
IIH患者的平均年龄为37.8±12.02岁。在IIH患者中,27例(84%)为女性,5例(16%)为男性。初始VEP值与视野检查结果(p=0.011)和视力(p=0.040)之间存在统计学显著关联。此外,在右侧(p<0.001)和左侧P100值方面,对照组与IIH患者之间存在统计学显著差异(p<0.001)。IIH患者初始VEP中有18例(56%)为病理性,第二次VEP中有14例(44%)为病理性,这种差异无统计学意义(p=0.125)。
检测到VEP P100值与疾病严重程度之间的关系,但未证明在IIH患者随访中监测VEP值的重要性。