Campbell Erin J, Jin Shubo, Lawrence Andrew J
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia.
Physiol Behav. 2019 Oct 15;210:112638. doi: 10.1016/j.physbeh.2019.112638. Epub 2019 Aug 2.
Environmental enrichment during periods of abstinence can reduce the risk of relapse to drug-seeking behavior. We trained rats to self-administer alcohol in one environment (Context A), then punished their alcohol-reinforced lever responses in a different environment using contingent foot shock (Context B). Rats were then kept in forced abstinence in either standard housing or environmental enrichment conditions for 31 days. The following day, we examined alcohol seeking behavior. We found a significant reduction in alcohol seeking behavior in Context A after environmental enrichment. Our results suggest that environmental enrichment can reduce alcohol seeking behavior following a period of abstinence.
禁欲期间的环境丰富化可以降低复吸寻求药物行为的风险。我们训练大鼠在一种环境（环境A）中自我给药酒精，然后在不同环境中使用偶然的足部电击惩罚它们的酒精强化杠杆反应（环境B）。然后将大鼠在标准饲养或环境丰富条件下强制禁欲31天。第二天，我们检查了酒精寻求行为。我们发现环境丰富化后，环境A中的酒精寻求行为显著减少。我们的结果表明，环境丰富化可以减少禁欲一段时间后的酒精寻求行为。
