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Immune therapy, a double-edged sword for oncolytic viruses.

作者信息

McCormack Ryan M, Kaur Balveen

机构信息

Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston , Houston , TX , USA.

出版信息

Expert Opin Biol Ther. 2019 Nov;19(11):1111-1113. doi: 10.1080/14712598.2019.1650911. Epub 2019 Aug 6.

DOI:10.1080/14712598.2019.1650911
PMID:31382785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6863343/
Abstract
摘要

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PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.溶瘤单纯疱疹病毒通过表达 PTEN 诱导 T 细胞介导的肿瘤清除。
Nat Commun. 2018 Nov 27;9(1):5006. doi: 10.1038/s41467-018-07344-1.
2
Armed oncolytic viruses: A kick-start for anti-tumor immunity.武装溶瘤病毒：抗肿瘤免疫的启动剂。
Cytokine Growth Factor Rev. 2018 Jun;41:28-39. doi: 10.1016/j.cytogfr.2018.03.006. Epub 2018 Mar 19.
3
Oncolytic Virotherapy Blockade by Microglia and Macrophages Requires STAT1/3.溶瘤病毒治疗被小胶质细胞和巨噬细胞阻断需要 STAT1/3。
Cancer Res. 2018 Feb 1;78(3):718-730. doi: 10.1158/0008-5472.CAN-17-0599. Epub 2017 Nov 8.
4
Randomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma.随机、开放标签的 II 期研究评估了替莫唑胺联合伊匹单抗与伊匹单抗单药治疗晚期不可切除黑色素瘤患者的疗效和安全性。
J Clin Oncol. 2018 Jun 10;36(17):1658-1667. doi: 10.1200/JCO.2017.73.7379. Epub 2017 Oct 5.
5
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.巨噬细胞极化通过联合免疫病毒疗法和免疫检查点阻断促进胶质母细胞瘤的根除。
Cancer Cell. 2017 Aug 14;32(2):253-267.e5. doi: 10.1016/j.ccell.2017.07.006.
6
Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.武装溶瘤病毒通过 CD40 和 4-1BB 信号诱导的肿瘤基质重塑和免疫激活。
Clin Cancer Res. 2017 Oct 1;23(19):5846-5857. doi: 10.1158/1078-0432.CCR-17-0285. Epub 2017 May 23.
7
Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy.与 CTLA4 和 PD1 阻断免疫疗法相关的心脏毒性。
J Immunother Cancer. 2016 Aug 16;4:50. doi: 10.1186/s40425-016-0152-y. eCollection 2016.
8
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.与抗CTLA-4抗体相关的免疫相关不良事件：系统评价与荟萃分析。
BMC Med. 2015 Sep 4;13:211. doi: 10.1186/s12916-015-0455-8.
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Clin Cancer Res. 2015 Jul 15;21(14):3274-85. doi: 10.1158/1078-0432.CCR-14-3118. Epub 2015 Mar 31.
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Cancer Cell. 2014 Jun 16;25(6):846-59. doi: 10.1016/j.ccr.2014.05.016. Epub 2014 Jun 2.