在慢性肾移植功能障碍中，循环 TFH 向 Tfr 的比值增加：一项初步研究。
Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study.
机构信息
Department of Laboratory Medicine, West China Hospital, Sichuan University, No.37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan, China.
Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
出版信息
BMC Immunol. 2019 Aug 5;20(1):26. doi: 10.1186/s12865-019-0308-x.
BACKGROUND
T follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit Tfh-B cell interaction.
METHODS
To identify whether circulating Tfh (cTfh) and Tfr (cTfr) cells contribute to chronic renal allograft dysfunction (CAD), 67 kidney transplant recipients (34 recipients with CAD, 33 recipients with stable function) were enrolled. The frequency of cTfh and cTfr cells, the level of serum CXCL13 were measured.
RESULTS
The frequency of cTfr cells in CAD group was significantly lower than that in stable group (0.31% vs 0.68%, P = 0.002). The cTfh to cTfr ratio in CAD group was significantly higher than that in stable group (55.4 vs 25.3, P = 0.013). Serum CXCL13 in CAD group was significantly higher than stable group (30.4 vs 21.9 ng/ml, P = 0.025). After linear regression analysis, the cTfh to cTfr ratio was an independent risk factor for estimated glomerular filtration rate (eGFR) in recipients (standardized coefficient = - 0.420, P = 0.012). After logistic regression analysis, the cTfh to cTfr ratio was an independent risk factor for CAD (OR = 1.043, 95%CI = 1.004-1.085, P = 0.031).
CONCLUSION
The imbalance between cTfh and cTfr cells contribute to the development of CAD.
背景
滤泡辅助 T 细胞（Tfh）在控制 B 细胞分化和抗体产生中发挥作用。滤泡调节性 T 细胞（Tfr）抑制 Tfh-B 细胞相互作用。
方法
为了确定循环滤泡辅助 T 细胞（cTfh）和滤泡调节性 T 细胞（cTfr）是否参与慢性肾移植功能障碍（CAD），纳入了 67 名肾移植受者（34 名 CAD 受者，33 名功能稳定受者）。测量 cTfh 和 cTfr 细胞的频率以及血清 CXCL13 水平。
结果
CAD 组 cTfr 细胞的频率明显低于稳定组（0.31%比 0.68%，P=0.002）。CAD 组 cTfh 与 cTfr 的比值明显高于稳定组（55.4 比 25.3，P=0.013）。CAD 组血清 CXCL13 明显高于稳定组（30.4 比 21.9ng/ml，P=0.025）。经线性回归分析，cTfh 与 cTfr 的比值是受者估算肾小球滤过率（eGFR）的独立危险因素（标准化系数=-0.420，P=0.012）。经逻辑回归分析，cTfh 与 cTfr 的比值是 CAD 的独立危险因素（OR=1.043，95%CI=1.004-1.085，P=0.031）。
结论
cTfh 与 cTfr 细胞失衡导致 CAD 的发生。
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