Division of Transplantation, Department of Surgery, Houston Methodist Hospital, Houston, TX, United States.
Division of Transplant Immunology, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, United States.
Front Immunol. 2022 Aug 9;13:895157. doi: 10.3389/fimmu.2022.895157. eCollection 2022.
The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting of organ transplantation, is dependent on this B-cell response, which does not appear to be halted by current immunosuppressive regimens which are targeted at T cells. There is emerging evidence that shows that B cells have a diverse response to solid organ transplantation that extends beyond plasma cell antibody production. In this review, we discuss the mechanistic pathways of B-cell activation and differentiation as they relate to the transcriptional regulation of germinal center B cells, plasma cells, and memory B cells in the setting of solid organ transplantation.
B 细胞对抗原刺激的反应的转录调控是复杂的，涉及到来自 T 细胞相互作用的细胞因子和转录因子的复杂动态信号网络。在器官移植的背景下，长期同种异体免疫依赖于 B 细胞反应，而目前针对 T 细胞的免疫抑制方案似乎并没有阻止这种反应。有新的证据表明，B 细胞对实体器官移植有多种反应，超出了浆细胞抗体产生的范围。在这篇综述中，我们讨论了 B 细胞激活和分化的机制途径，以及它们与实体器官移植中生发中心 B 细胞、浆细胞和记忆 B 细胞的转录调控的关系。
