Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt.
J Nanosci Nanotechnol. 2020 Feb 1;20(2):890-899. doi: 10.1166/jnn.2020.16923.
Chitosan decorated copper nanoparticles (CS/CuNPs) catalysts were synthesized via reduction methods utilizing green protocol. The CS/CuNPs hybrid catalysts were tested for the synthesis of quinoline derivatives utilizing one-pot multicomponent reaction (MCR) under ultrasonic irradiation. The optimized CS/CuNPs catalyst that provided good conversion reaction yield and high turnover frequency (TOF) was characterized using Fourier transform infrared (FTIR), thermogravimetric analyses (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS) techniques. Generalization of the scope of the proposed catalytic process was studied using different aldehydes. Excellent products yield and high TOF in even shorter reaction time (~5 min) was attained. Recyclability performance of the catalyst over five times re-use without detectable loss in product yield was recorded. The current method is green process utilizing environmentally benign catalyst and considered to be promising sustainable protocol for the synthesis of fine chemicals.
壳聚糖修饰的铜纳米粒子（CS/CuNPs）催化剂是通过绿色协议利用还原方法合成的。CS/CuNPs 杂化催化剂在超声辐射下，通过一锅多组分反应（MCR）用于合成喹啉衍生物。使用傅里叶变换红外（FTIR）、热重分析（TGA）、X 射线衍射（XRD）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和 X 射线光电子能谱（XPS）技术对提供良好转化率和高周转频率（TOF）的优化 CS/CuNPs 催化剂进行了表征。通过不同的醛研究了所提出的催化过程的范围的概括。即使在更短的反应时间（~5 分钟）内，也能获得优异的产物收率和高 TOF。催化剂经过五次重复使用，产物收率没有明显下降，可重复使用性能良好。该方法是一种利用环境友好型催化剂的绿色工艺，被认为是一种有前途的可持续精细化学品合成方法。
