Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Visionsgatan 4, Stockholm 17177, Sweden; Science for Life Laboratory, Tomtebodavägen 23a, Stockholm 171 65, Sweden.
Gastroenterol Clin North Am. 2019 Sep;48(3):331-342. doi: 10.1016/j.gtc.2019.04.002. Epub 2019 Jun 12.
The interaction between drug use, the microbiome, and the host is complex and multidimensional. Drugs and the microbiota may be risk factors or protective factors for disease. These interactions may explain interpersonal variations in drug efficacy and toxicity, but also interpersonal variations in microbiota composition and functioning, and potential (long-term) side effects from drugs.
药物使用、微生物组和宿主之间的相互作用是复杂和多维的。药物和微生物群可能是疾病的危险因素或保护因素。这些相互作用可以解释药物疗效和毒性的个体间差异，也可以解释微生物群落组成和功能的个体间差异，以及药物的潜在（长期）副作用。
