Faculty of Medical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Graduate Program in Biological Sciences (PPGBio) and Department of Pharmaceutical Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
Med Hypotheses. 2019 Sep;130:109273. doi: 10.1016/j.mehy.2019.109273. Epub 2019 Jun 11.
In this hypothesis paper, we propose that hoarding disorder may be an ancestral mammalian behavior, possibly hard-wired but dormant in present-day humans, that can be activated by traumatic experiences. To support this claim, we describe hoarding in ancestral mammals and provide examples of recurrence of traits, or atavisms, in humans and other mammals, highlighting its implications for neuropsychiatric diseases. We highlight the potential of using shrews as animal models for hoarding behavior and, considering the current knowledge on the molecular underpinnings of the disorder, we also point to limitations of the proposed connection.
在这篇假说论文中，我们提出囤积症可能是一种祖先哺乳动物的行为，在现代人类中可能是先天的但处于休眠状态，可以通过创伤性经历激活。为了支持这一说法，我们描述了祖先哺乳动物中的囤积行为，并提供了人类和其他哺乳动物中特征重现（返祖现象）的例子，强调了其对神经精神疾病的影响。我们强调了使用鼩鼱作为囤积行为动物模型的潜力，并考虑到目前对该疾病分子基础的了解，我们还指出了所提出的联系的局限性。
