Internal Medicine and Stroke Care Ward, Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, "G. D'Alessandro", University of Palermo, Italy.
Internal Medicine and Stroke Care Ward, Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, "G. D'Alessandro", University of Palermo, Italy.
Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1118-1125. doi: 10.1016/j.numecd.2019.06.010. Epub 2019 Jun 20.
Although some authors evaluated the relationship between adherence to the Mediterranean Diet (MeDi) and both ischemic and hemorrhagic stroke, hemorrhagic stroke alone is not yet examined.
We conducted a retrospective study to evaluate the relationship between adherence to MeDi and intracerebral hemorrhage (ICH) and different locations of ICH (ganglionic/internal capsule, brainstem/cerebellum, or lobar).
We analyzed charts and collected data of all consecutive patients with ICH admitted to our Internal Medicine Ward from 2005 to 2014. A scale indicating the degree of adherence to the traditional MeDi Score was constructed.
When compared with 100 subjects without ICH, 103 subjects with ICH had significantly higher mean values of LDL (91.1 ± 38.7 mg/dl vs. 79.2 ± 34.4 mg/dl; p = 0.031), triglycerides (118.9 ± 62.9 mg/dl vs. 101.6 ± 47.6 mg/dl; p = 0.026), and proteinuria (32.6 ± 50.0 mg/dl vs. 18.1 ± 39.6 mg/dl; p=0.024) and a significantly lower mean MeDi Score (3.9 ± 1.0 vs. 7.0 ± 1.4; p < 0.0001). In a multiple regression analysis, smoking, diastolic blood pressure (DBP), and the MeDi Score remained significantly associated with ICH. We also observed a significantly lower mean MeDi Score in the lobar location group when compared with the ganglionic/internal capsule group (4.3 ± 1.0 vs. 3.5 ± 0.9; p < 0.0005).
Our findings regarding the higher prevalence of ICH in patients with lower adherence to MeDi may be related to the fact that patients with lower MeDi Score exhibit a worse cardiovascular risk profile with increased risk factors such as hypertension and dyslipidemia.
尽管有些作者评估了地中海饮食（MeDi）的依从性与缺血性卒中和出血性卒中的关系，但单独的出血性卒中尚未得到研究。
我们进行了一项回顾性研究，以评估 MeDi 的依从性与颅内出血（ICH）以及 ICH 的不同部位（神经节/内囊、脑干/小脑或脑叶）之间的关系。
我们分析了 2005 年至 2014 年期间入住我们内科病房的所有连续ICH 患者的图表并收集了数据。构建了一个表明对传统 MeDi 评分的依从程度的量表。
与 100 例无 ICH 的患者相比，103 例 ICH 患者的 LDL（91.1 ± 38.7mg/dl 与 79.2 ± 34.4mg/dl；p=0.031）、甘油三酯（118.9 ± 62.9mg/dl 与 101.6 ± 47.6mg/dl；p=0.026）和蛋白尿（32.6 ± 50.0mg/dl 与 18.1 ± 39.6mg/dl；p=0.024）的平均值显著更高，而 MeDi 评分的平均值显著更低（3.9 ± 1.0 与 7.0 ± 1.4；p<0.0001）。在多变量回归分析中，吸烟、舒张压（DBP）和 MeDi 评分与 ICH 仍显著相关。与神经节/内囊组相比，我们还观察到脑叶部位组的 MeDi 评分明显更低（4.3 ± 1.0 与 3.5 ± 0.9；p<0.0005）。
我们关于 MeDi 依从性较低的患者 ICH 发生率较高的发现可能与以下事实有关，即 MeDi 评分较低的患者心血管风险状况更差，存在高血压和血脂异常等更多危险因素。
