Halal Research Center of IRI, FDA, Tehran, Iran; Department of Modern Sciences and Technologies, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
Trends Endocrinol Metab. 2019 Sep;30(9):672-683. doi: 10.1016/j.tem.2019.07.006. Epub 2019 Aug 2.
There is evidence of the critical role of efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, in vascular cell homeostasis and protection against atherosclerosis. Specific microRNAs (miRs) can regulate atherogenesis by controlling the accumulation of professional phagocytes (e.g., macrophages) and nonprofessional phagocytes (i.e., neighboring tissue cells with the ability to acquire a macrophage-like phenotype) within the arterial wall, the differentiation of phagocytes into foam cells, the efferocytosis of apoptotic foam cells by phagocytes, and the phagocyte-mediated inflammatory response. A better understanding of the mechanisms involved in miR-regulated phagocyte function might lead to novel therapeutic antiatherosclerotic strategies. In this review, we try to shed light on the relationship between miRs and cellular players in the process of efferocytosis in the context of atherosclerotic plaque and their potential as molecular targets for novel antiatherosclerotic therapies.
有证据表明，细胞凋亡细胞（AC）的清除作用即吞噬作用在血管细胞稳态和抗动脉粥样硬化中起着关键作用。特定的 microRNAs（miRs）可以通过控制动脉壁内专业吞噬细胞（如巨噬细胞）和非专业吞噬细胞（即具有获得巨噬细胞样表型能力的邻近组织细胞）的积累、吞噬细胞向泡沫细胞的分化、吞噬细胞对凋亡泡沫细胞的吞噬作用以及吞噬细胞介导的炎症反应，来调节动脉粥样硬化的发生。更好地了解 miR 调节的吞噬细胞功能涉及的机制可能会导致新的抗动脉粥样硬化治疗策略。在这篇综述中，我们试图阐明 miR 与动脉粥样硬化斑块中吞噬作用过程中的细胞参与者之间的关系，以及它们作为新型抗动脉粥样硬化治疗分子靶点的潜力。
