Institute of Biology, University of Szczecin, Szczecin, Poland.
Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.
Scand J Immunol. 2023 May;97(5):e13251. doi: 10.1111/sji.13251. Epub 2023 Jan 10.
This paper presents the role of macrophage efferocytosis, the process of elimination of apoptotic bodies-elements formed during vascular atherosclerosis. The mechanisms of macrophage efferocytosis are presented, introducing the specific signals of this process, that is, 'find me', 'eat me' and 'don't eat me'. The role of the process of efferocytosis in the formation of vascular atherosclerosis is also presented, including the factors and mechanisms that determine it, as well as the factors that determine the maintenance of homeostasis in the vessels, including the formation of vascular atherosclerosis.
本文介绍了巨噬细胞胞噬作用的作用,即消除血管动脉粥样硬化过程中形成的凋亡小体(细胞碎片)的过程。本文介绍了巨噬细胞胞噬作用的机制,引入了这个过程的特定信号,即“找我”、“吃我”和“别吃我”。本文还介绍了胞噬作用在血管动脉粥样硬化形成中的作用,包括决定它的因素和机制,以及决定血管内稳态的因素,包括血管动脉粥样硬化的形成。