Barone F C, Wayner M J, Weiss C S, Almli C R
Brain Res Bull. 1979 Mar-Apr;4(2):267-82. doi: 10.1016/0361-9230(79)90291-0.
The effects of gastric water infusion and distension were examined in neurons from various parts of the rat brain. Neurons in the lateral preoptic-lateral hypothalamic-medial forebrain bundle (LPA-LH-MFB) neuropil were sensitive to gastric water infusion and distension. Cells randomly selected and examined in other brain areas were less sensitive to the same stimulation which indicated that the effects were relatively specific. The results, in terms of changes in neuronal discharge frequency from an established baseline, indicate that many cells in the lateral preoptic-lateral hypothalamic-medical forebrain bundle area are affected by intragastric water infusion and gastric distension within a time period during which changes in drinking would normally occur. These neurons were also affected differentially by acute water deprivation. LPA-LH-MFB neurons in 24 hr water deprived animals were significantly more sensitive to water infusions and less sensitive to stomach distension when compared to cells recorded in animals maintained on ad lib eating and drinking. Some of these same neurons were also sensitive to changes in the extracellular concentrations of sodium and glucose. The results are discussed in terms of the involvement of the lateral preoptic-lateral hypothalamic-medial forebrain bundle neuropil in ingestive behavior.
研究了胃内注水和扩张对大鼠脑不同部位神经元的影响。视前外侧 - 下丘脑外侧 - 内侧前脑束（LPA-LH-MFB）神经纤维网中的神经元对胃内注水和扩张敏感。在其他脑区随机选择并检查的细胞对相同刺激的敏感性较低，这表明这些影响具有相对特异性。从既定基线测量的神经元放电频率变化结果表明，在正常饮水变化发生的时间段内，视前外侧 - 下丘脑外侧 - 内侧前脑束区域的许多细胞受到胃内注水和胃扩张的影响。这些神经元对急性缺水也有不同的反应。与自由饮食饮水的动物中记录的细胞相比，24小时缺水动物中的LPA-LH-MFB神经元对注水更敏感，对胃扩张不太敏感。其中一些相同的神经元对细胞外钠和葡萄糖浓度的变化也敏感。讨论了视前外侧 - 下丘脑外侧 - 内侧前脑束神经纤维网在摄食行为中的作用。
